Effect of maternal supplementation with essential fatty acids and conjugated linoleic acid on metabolic and endocrine development in neonatal calves

We tested the hypothesis that maternal supply of essential fatty acids (EFA), especially ?-linolenic acid, and conjugated linoleic acid (CLA), affects glucose metabolism, endocrine regulation energy metabolism growth, intestinal development neonatal calves. studied calves from dams received an abomasal infusion 76 g/d coconut oil (CTRL; n = 9), 78 linseed 4 safflower (EFA; 38 Lutalin (BASF SE) containing 27% cis-9,trans-11 trans-10,cis-12 CLA (CLA; or a combination EFA (EFA+CLA; 11) during last 63 d gestation early lactation. Calves colostrum transition milk their own dam for first 5 life. Insulin-like growth factor (IGF)-I, leptin, adiponectin concentrations were measured in milk. Blood samples taken before intake, 24 h after birth, 3 to life morning feeding measure metabolic traits plasma. On life, expenditure was evaluated by bolus injection NaH13CO3 determination CO2 appearance rate. 4, additional blood evaluate first-pass uptake 13CO2 enrichment [13C6]-glucose intravenous [6,6-2H2]-glucose injection, as well postprandial changes glucose, nonesterified (NEFA), insulin, glucagon. 5, killed 2 small mucosa histomorphometric measurements. The IGF-I, adiponectin, leptin decreased lactation all groups, higher than CTRL cows. Plasma concentration intake non-EFA lower non-CLA IGF-I on 1 EFA+CLA indicated overall effect, with plasma Postprandial NEFA lowest rise insulin increased groups Maternal treatment did not affect uptake, but faster Crypt depth lower, ratio villus height crypt ilea Elevated immediately birth may indicate improved energetic status when are supplemented EFA. supplementation influenced affected factors related response.